This is going to sound terrible, but the best advice I have is to be willing to try lots of different software settings and not get frustrated. But I've never had "don't get frustrated" be useful advice for me...
Per
mhackney's advice, I've been using the Prusa version of Slic3r lately and been mostly happy with the results. (Plus the 3d printed fishing reels he makes and sells are have flawless first layer quality.) You can get it here:
https://github.com/prusa3d/Slic3r/releases
In your situation, I think my plan would be to first make the smallest print I can that has those first layer infill problems. If you can make a small model that reliably gets the problems to happen quickly, then you can use that to test ideas with less time involved. (Of course, we're still talking about 3d printing taking over your life for a while, but hopefully that's part of the appeal.)
There's a few things going on there, like:
- The long straight gap along the whole top and bottom of the print. (That's pretty bad, most slicers should do better than that.)
- The irregularly shaped gaps like around and between "ER".
- Maybe that round gap inside the first O, but I think that one might be a very similar artifact to the top one.
- The really tiny gap between the hole and the corner. (For most slicers, that might be a hard one to always fix.)
Then, as IMBoring25 said, you're going to have quite a few options to play with, depending on which slicer you're using. The big long gaps look to me like the slicer just didn't plan good enough lines to cover the whole area, but I can't rule out under-extrusion (extrusion rate) or layer height issues just from one picture. For little gaps in odd places, there's a lot of potential culprits like retraction or bed adhesion. e.g. If your retraction left a little bit of plastic behind while it was moving the print head to fill in a gap, it might not extrude enough right away when it gets there, or the plastic might not instantly, perfectly adhere, and it will drag a bit away from where it should be when it starts printing the infill.
One beginner approach (which I use frequently) is to calibrate your printer to start just a little low for the first print, so it's forced to squish the plastic down a little bit lower than perfectly 0.2 or 0.25 mm or whatever the first layer height is set to. When it starts printing, you'll see the plastic look flattened, and you have to be careful that you're not too far down.
This creates a little bit of "elephant foot" around the edges of the print that you might have to trim off later, but helps to guarantee that the entire first layer makes contact with the print bed and you end up with a smooth, line-free first layer. Some slicers (like the prusa slic3r) even include an "elephant foot compensation" setting for this.